Target inhibition of Toll-like receptor 4 signaling pathway and necrotizing enterocolitis / 中华围产医学杂志

The pathogenesis of neonatal necrotizing enterocolitis (NEC) is still unclear. Toll-like receptor 4 (TLR4) signaling pathway, mediated by TLR4 in the intestinal epithelial cells, is considered to play an important role in activating inflammatory storm in NEC. This paper elaborates the association between NEC and the inhibition of TLR4 signal pathway and its upstream and downstream signal targets, critical pattern recognition receptors, and negative regulation of TLR4 by certain receptors to gain more insight into possible target interventions for NEC.